Certified Medical-Surgical Registered Nurse Practice Test 2025 - Free Practice Questions and Study Guide

ACE inhibitors are a well-established class of medications commonly utilized in the pharmacological management of hypertension. They work by inhibiting the angiotensin-converting enzyme, which is crucial in the body’s renin-angiotensin-aldosterone system (RAAS). This inhibition leads to a decrease in the formation of angiotensin II, a potent vasoconstrictor, resulting in vasodilation and a subsequent reduction in blood pressure. Additionally, ACE inhibitors decrease aldosterone secretion, promoting sodium excretion and reducing blood volume, further aiding in the management of hypertension.

While beta-blockers, calcium channel blockers, and diuretics also effectively lower blood pressure, ACE inhibitors are specifically known for their unique action on the RAAS, making them a first-line treatment in many guidelines for hypertension management, especially in patients with additional conditions like heart failure or chronic kidney disease. Their renal protective effects and ability to reduce cardiovascular risk further solidify their role in treating hypertension.